New research suggests that patients who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Research printed in a major medical journal demonstrates that while overweight people often shed about a fifth of their total mass while using the jabs, the weight returns at an average rate of nearly a kilo each month after stopping.
"Individuals purchasing these treatments should be aware of the potential of rapid weight regain when the medication is stopped," cautioned researcher Dr. Susan Jebb.
That rate of recovery suggests a return to pre-treatment mass within about a year and a half.
Comparing Approaches
The research, which reviewed dozens of studies involving thousands of participants, contrasted the results of these new drugs with older methods.
The team note that people who shed pounds through dieting typically experience a more gradual creep back—approximately 100 grams monthly—after stopping.
Explaining the Fast Rebound
Experts propose the mode of action of the drugs accounts for the accelerated weight return.
These medications copy a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of GLP-1 concentrations far above than normal may cause the system to generate a reduced amount of its endogenous hormone, and could reduce sensitivity to its actions," explained Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this hormone supplement results in hunger is uncontrolled, making binge eating far more likely."
A Lifelong Issue?
Medical guidelines recommend the injections for individuals with obesity-related health risks, alongside prescribed lifestyle changes.
Many experts contend that, given the high risk of weight regain, the treatment might need to be long-term.
This perspective is echoed by drug manufacturers, who say that the findings "emphasize the long-term character of obesity," akin to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have come off the jabs report a powerful return of cravings.
"It was like a trigger that goes on and I was suddenly extremely hungry," said one woman.
The struggle is compounded if users have not adopted permanent lifestyle or habit changes during treatment.
Widespread Interest
Recent estimates suggest that millions of adults in the UK have used these injections in the past year, with interest remaining high.
- Adoption is more common among females compared to men.
- The 40s and 50s demographic shows the highest level of interest.
- A large proportion access the drugs through private healthcare rather than public health services.
In conclusion, experts caution that while these medications are potent tools for shedding pounds, they are not a permanent solution and long-term success likely depends on combined behavioural changes.
